Pdf taste is mainly a function of taste buds in the mouth. Formulating orodispersible, melt in mouth, buccal tablet and other formulations which comes in contact with taste buds taste is one of critical factor to be consider. The dried granules were mixed with sugar and hpc to give taste masked dry syrup 34. To overcome this problem, many techniques have been developed to mask the bitter taste of drugs. Introduction in earlier days it was believed that the drugs having bitter taste are more efficient as. Many drug activities are intensely bitter or have other aversive sensory attributes that can be challenging to overcome. When drug products and not properly taste masked, dosing compliance and health outcomes suffer. Bitter taste, taste buds, taste masking techniques. Coating of drugs using a suitable polymer by coating one avoid the contact of bitter drug by preventing release of bitter drug in oral cavity. Salt butterscotch, maple, apricot, peach, vanilla, wintergreen mint. Pdf undesirable taste is one of several important formulation problems that are encountered with certain drugs the problem of bitter and obnoxious. Thus the taste of the drug is masked without interrupting the drug release profile. This step can be doing for taste masking of slightly bitter tasting drug.
Moreover, microencapsulation of a potent bitter drug is not enough to provide the taste masking of liquid oral suspensions 4,5. Taste masking approaches for unpleasant taste drugs. Pdf taste masking techniques for bitter drugsan overview. Senopsys scientists are expert in both taste assessment and taste masking. Taste masking techniques in the pharmaceutical industry. The drug was mixed with molten steryl alcohol at 70 c and eudragit 100. Sweeteners, being highly water soluble, dissolve in saliva and coat the taste buds, thereby retarding the interaction of bitter api with taste buds. Basis of choosing a flavor complementary to existing flavor of the drug known popularity of particular flavors age of patients allergy. Flavoring agents for taste masking basic taste masking agents. Taste physiology and taste masking of bitter drugs with.
Taste is mainly a function of taste buds in the mouth. Bitter wild cherry, walnut, chocolate, mint, anise. Developments in tastemasking techniques for traditional. Taste masking for palatable drug products senopsys. This is one of the simplest techniques used in taste masking. Proper selection of coating material will mask taste of bitter drug completely without affecting drug release profile. Some orally administered drugs exhibit bitter taste. Steryl alcohol and eudragit 100 were used for taste masking of bitter macrolide antibiotic. The liquid composition utilizes a reverse enteric coating, which is soluble in acid ph of the stomach generally. Excipients such as sweeteners and flavorants can be added to taste mask bitter api.